Walking Wolf is the orphaned son of white settlers, found as an infant and raised to be a proud Comanche warrior. He also happens to be a werewolf. When he loses control of his darker nature, Walking Wolf heads out into the white man's world to learn more about who - and what - he is.

This is his story of self-discovery as he travels the Old West, crossing the paths of deranged serial killers, a traveling medicine show, a vampire gunslinger, even a fellow werewolf, as well as such historical figures as Quanah Parker and Sitting Bull. But of all the dangers he finds himself facing, none is as deadly as the bounty hunter known as Witchfinder Jones, who holds the secret of Walking Wolf's origins.