Three interrelated stories make up the plot of The Suicide Club. They each stand on their own, but there is an overall plot that brings them together. It centers around the hero, Prince Florizel of Bohemia. He attempts to solve the mystery of a strange club that turns out to have a very different purpose than its name suggests.

The three stories in the trilogy are: "Story of the Young Man with the Cream Tarts", "Story of the Physician and the Saratoga Trunk", and "The Adventure of the Hansom Cab". Also included are dramatized versions of two of Stevenson's most famous short stories: "Markheim" and "The Sire de Maletroit's Door".