An unnamed narrator pieces together the story of an area known by the locals as the "blasted heath" in the wild hills west of the fictional town of Arkham, Massachusetts. The narrator discovers that many years ago a meteorite crashed there, poisoning every living being nearby; vegetation grows large but foul tasting, animals are driven mad and deformed into grotesque shapes, and the people go insane or die one by one.

First appearing in the September 1927 edition of Hugo Gernsback's science fiction magazine Amazing Stories, "The Colour Out of Space" became one of Lovecraft's most popular works, and remained his personal favorite of his short stories.