At the center of Home Again is Madelaine - a brilliant cardiologist, a loving mother, a tender friend, and a woman full of self-doubt. It is also the story of her confused and angry daughter, Lina, and of the two very different men Madelaine loves: Francis, a priest searching for his faith, and Angel, a talented but cynical man with a broken heart. When tragedy suddenly brings them all together, they must learn to forgive the betrayals of the past and find the courage to love again.