An ancient fundamentalist organization executes several attacks simultaneously across the globe. A deadly viral compound is unleashed in the Pentagon, and the airborne virus turns the building's population into zombies. A Secret Service agent, coerced by the terrorists to assassinate several heads of state, sends the world into chaos.

Meanwhile, a former army officer stranded in the Midwest is forced to fight for his life while his fiancé is trapped in the Washington, DC quarantine zone and a desperate US Army Delta team searches for a way to end the madness.

They must each fight for their own survival as the nation battles to end the zombie threat before it becomes a global pandemic.