“Those who the gods wish to destroy, they first make mad.”

Devastated by grief after the death of her daughter, Detective Sergeant Jamie Brooke returns to investigate the murder of a prominent psychiatrist in the old hospital of Bedlam in London.

As she delves into the history of madness, museum researcher, Blake Daniel, helps with the case, only to discover that his own family is entwined with the shadowy forces that seek to control the minds of the mad.

As the body count rises, and those she loves are threatened, Jamie discovers that the tendrils of conspiracy wind themselves into the heart of the British government. Can she stop the killer before madness takes its ultimate revenge?