Dr. Andrew Doran is back! Narrowly saving the world from the cosmic advance of the Nazi armies, Andrew Doran is loathing with his new position as dean of Miskatonic University. The duties of a dean are too slow for the lifestyle that Andrew had become accustomed to, but he doesn't have to wait long until he finds that the previous dean had sold documents to the Nazis direct from the library of Miskatonic University. Specifically, the documentation of a fateful voyage by Dr. William Dyer to the Antarctic and the horrors he faced there.

Knowing that the German army won't hesitate to travel to the Antarctic and seize the alien weaponry that is held there, Andrew and his faithful companion, Leo, embark on an adventure to find the missing Dr. Dyer and beat the Nazis to the lost city in the frozen wasteland at the end of the world.

To make matters worse, Andrew is battling his own demons in the form of the physical manifestation of his own insanity. Can Andrew find the missing William Dyer and beat the Nazi menace to the cache of weapons before his insanity literally consumes him?