In the harsh winter of a postapocalyptic landscape, Rachel Wheeler and her companions hole up in an Appalachian compound established by her notorious grandfather.

A rogue military platoon plans to seize the compound and control the small band of survivors. At the same time, violent mutants organize into a tribe that threatens to wipe out the human race. Rachel is caught in the middle as she undergoes mutations herself, driven by an urge to kill those around her while drawn to the mysterious Zapheads.

Rachel soon discovers the mutants are more than they appear to be. But will she remain human long enough to use their secrets against them?